Xiangbin Ruan (Cham, 阮祥斌), MD, PhD, Postdoc Associate, email: xiangbinruan AT uchicago.edu
Xiangbin graduated from Wuhan University in 2010 with an MD. He obtained PhD from Peking Union Medical College in Prof. Boqin Qiang’s lab, where he was co-mentored by Prof. Weimin Zhong (Yale). His PhD thesis described roles of microRNAs in cortical layer formation and their cross-talk with Wnt signaling. Xiangbin is interested in RNA-mediated biological processes in neural development.
Representative publications (*Co-first authors):
Ruan, X*, Hu K*, Yang Y*, Yang R, Tseng E, Kang B, Kauffman A, Zhong R, Zhang X. (2024) Cell-type-specific splicing of transcription regulators and Ptbp1 by Rbfox1/2/3 in the developing neocortex. J Neurosci. Epub 20241112.
Ruan, X., Hu, K., Zhang, X. (2023) PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing. Nature Communications. 14(1):3275.
Ruan, X.*, Kang, B.*, Qi, C., Lin, W., Wang, J., & Zhang, X. (2021) Progenitor cell diversity in the developing mouse neocortex. Proceedings of the National Academy of Sciences, 118(10).
Ruan, X., Liu, G., Zhou, J., Chen, P., Sun, C., Liu, W., Wu, C., Hou, L., Yin, B., Qiang, B. and Shu, P., (2021) Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain. Cerebral Cortex. 31(9), 4078-4091.
Shu P.*, Wu C.*, Ruan X., Liu W., Hou L., Fu H., Wang M., Liu C., Zeng Y., Chen P., Yin B., Yuan J., Qiang B., Peng X., and Zhong W.(2019) Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex. Developmental cell. 49, 764-785.