Xiangbin Ruan, MD, PhD, Postdoc Associate, email: xiangbinruan AT uchicago.edu

Xiangbin graduated from Wuhan University in 2010 with an MD. He obtained PhD from Peking Union Medical College in Prof. Boqin Qiang’s lab, where he was co-mentored by Prof. Weimin Zhong (Yale). His PhD thesis described roles of microRNAs in cortical layer formation and their cross-talk with Wnt signaling. Xiangbin is interested in RNA-mediated biological processes in neural development.

Representative publications:

1.    Ruan, X., Hu, K., Zhang, X. (2023) PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing. Nat Commun. 2023;14(1):3275.

2.    Ruan, X.*, Kang, B.*, Qi, C., Lin, W., Wang, J., & Zhang, X. (2021). Progenitor cell diversity in the developing mouse neocortex. Proceedings of the National Academy of Sciences, 118(10). (*Co-first authors)

3.    Ruan, X., Liu, G., Zhou, J., Chen, P., Sun, C., Liu, W., Wu, C., Hou, L., Yin, B., Qiang, B. and Shu, P., (2021) Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain. Cerebral Cortex, 31(9), 4078-4091.

4.    Shu P.*, Wu C.*, Liu W.*, Ruan X.*, Liu C., Hou L., Zeng Y., Fu H., Wang M., Chen P., Zhang X., Yin B., Yuan J., Qiang B., Peng X. (2019) The spatiotemporal expression pattern of microRNAs in the developing mouse nervous system. J Biol Chem. 294(10):3444-3453. (*Co-first authors)

5.   Shu P.*, Wu C.*, Ruan X., Liu W., Hou L., Fu H., Wang M., Liu C., Zeng Y., Chen P., Yin B., Yuan J., Qiang B., Peng X., and Zhong W.(2019) Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex. Developmental cell 49, 764-785.